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Dr. Clay Siegall, the founder of revolutionary drug company Seattle Genetics, has been at the forefront of the development of targeted cancer therapies since the beginning. After first becoming aware of the new class of drugs, while working at the National Cancer Institute, Dr. Siegall went on to lead a team of researchers at Bristol-Meyer-Squibb that gave birth to an entirely new form of targeted therapy, a class of drugs known as antibody drug conjugates.

Tinkering with nature’s most basic mechanics

The field of targeted therapy first started becoming an accepted part of the cancer research world throughout the late 80s and early 90s. During this time, great leaps forward in things like genomics and molecular biology allowed for techniques that were not previously possible. Targeted therapy, as a concept, developed as a way by which increased knowledge of genetic sequencing, protein structure and other detailed, molecular-level knowledge of microbiological processes could be used to specifically target malignant cells.

Many different methods of creating drugs that used the principles of targeted therapy were developed. There were two main branches of the targeted therapy approach, the creation of drugs that were cytotoxic and the creation of those which were cytostatic. Cytotoxic drugs involve delivery of an agent which kills cells into the tumor site and its cells. This is usually accomplished by use of enzymes or antibodies which specifically target the tumor cells using a sort of molecular handshake. By contrast, cytostatic drugs are agents which prevent further growth of the malignancy but don’t actually kill the tumor’s cells. The two approaches both have their respective merits, but each one uses radically different mechanisms to work its desired effects. Of the two, the class of cytotoxic drugs holds the most promise for developing a bona fide cure, but they also are the most difficult drugs to develop.

Dr. Siegall and his company have developed a class of cytotoxic drugs known as antibody drug conjugates. With one drug, Adcetris, already approved by the FDA for treatment of classic Hodgkin’s lymphoma, Seattle Genetics is well on its way to becoming the leading company in the search for cancer’s eventual cure.


Rona Borre is the CEO of Instant Alliance

Changing The Face Of Tech

The tech industry is often thought of as male dominated and elitist, but Rona Borre is doing everything she can to change that image. Through her work at Instant Alliance she helps companies in the tech and finance industries find workers from diverse background sin order to fill positions when needed. Her work isn’t the easiest work out there, but it is work that is needed and she does her job as well as she can.



How Instant Alliance Does This

The Instant Alliance is a human resources company specializing in finding the right tech workers for various in demand jobs.  Based on the hiring process is much more complicated than it seems. Looking at a resume can give you a glossary look at the qualifications of an individual, but it doesn’t tell the entire store. In order to understand everything about an individual you need to look deeper into their background. Instant Alliance looks at candidates and makes sure these are people who can work in teams and matches them with the companies that need them.

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About Rona Borre

Rona Borre is the CEO of Instant Alliance and a strong supporter of diversity in the workforce. Her work at Instant Alliance helps job applicants with the right qualifications find the jobs they want and fulfill those positions. Rona understands the tech industry is booming and there is a need to find people who can fill these positions and help the industry advance.

Lori Senecal is considered as one of the leading female executives in the field of global advertising. She is currently serving as the Global CEO of Crispin Porter + Bogusky (CP+B) which is considered one of the largest advertising firms in the world. While working here, Lori has proved her operational excellence in managing a number of global brands and expanding their business. She also had an amazing career in numerous other renowned organizations which puts her in the prestigious group female executives.

Lori earned her Bachelor of Commerce degree in Marketing & Finance from the prestigious McGill University. After this, she joined McCann Erickson in 2003 as the co-Founder of is TAG Ideation. She worked in this company for a long while till 2009 and assumed different positions including the role of President of its New York office between 2007 and 2009. During this time, she developed a strong network of large clients and partners across the world along with an in-depth knowledge in brand promotion on a global scale.

Considering her management style and strengths, Lori was offered the position of President and CEO at Kirshenbaum Bond Senecal + Partners in 2009. When Lori moved this company, a number of her ex-colleagues left McCann to work with her. In addition, a number of clients from McCann also switched along with Lori as they had more trust with Lori than her previous organization. Lori worked in this company till 2014 and then she joined MDC Partners as its President & CEO in September 2014. She has also been serving as the Global Executive Chairman of Kirshenbaum Bond Senecal + Partners since 2014. After a huge restructuring in this company in 2015, She has been serving as the Global CEO of CP+B overlooking its operations.

As a top executive, Lori has an intuitive approach to managing her clients, projects, and team members. She is always emphasizing on talents and strives to new and upcoming challenges. Under her strong management and strategic direction, CP+B has transformed from a small 250 employee local firm to a global advertising giant with more than 900 employees working for it. She has been highly acclaimed for her annotative digitally-led integrated communication strategies and brand management. She also played a vital role in developing a sense of innovation among her colleagues and shaping their career.

Apart from a busy career in advertising, Lori also spends her time to share industry insights and thought in different engagements and conferences. Very recently, she attended the NY Times conference that highlights achievements by female executives who represent the 3% of top executive positions in the industry. She was awarded the AWNY Game Changer Awards as well as Women to Watch for 2014 by Ad Age. Follow Lori  on twitter.


Successful people are often asked how they were able to achieve such great things. Eric Pulier is no different. He has risen to the top of the tech world. Therefore, it is no surprise that many people around the world would like to know how he got there. Eric is always happy to share some words of wisdom with young people who are hungry to succeed in the way that he did. This has led him to give many lectures around the United States where he tells his story and takes questions from members of the audience.


Eric is a graduate of Harvard University. However, he did not get a degree that has anything to do with computers or technology. Instead, Eric was initially interested in pursuing a career as an English literature professor. However, he soon discovered after college that this particular career choice was not right for him. He hooked up with a few people who were already heavily involved in the world of tech startups. They were nice enough to show Eric everything he needed to know in order to get a startup off the ground. He then used what he had learned in order to make his own startups like Akana and Desktone a success.


Eric often tells young people that there are several key factors that will determine if your startup is going to be profitable. He believes that a person’s ability to raise capital from investors is enormously important. Obviously, startups cost money. Therefore, you need to be able to make other people believe that investing in your particular startup is a wise business decision. It takes skill to be able to pitch a startup idea to venture capitalists who have things pitched to them every day. Eric also feels that hiring a good web designer is critical to your overall success. You need to be sure that your site looks good and functions properly. Obviously, having a sustainable business plan is something that you will need to have in order to keep your startup going in the months to come. Eric says that all of these things are necessary.


The Dallas based investment firm Highland Capital Management recently upped its stake in the Nexpoint Credit Strategies Fund. Highland Capital has looked to improve its financial position in the fund by investing in more shares. It now has over 793,000 shares which is the second most right behind another investment firm known as Morgan Stanley. The firm’s holdings consist of a total of 5% of the firm’s common stock. According to sources, James Dondero possesses 3 million shares and therefore has a considerable stake in the fund. His current holdings make up over 18% of the company’s total shares. As of the end of 2016, Highland Capital Management reported its current stake of ownership of $12 million worth of shares.


James Dondero is the co founder of Highland Capital Management. He has had a very long and successful career in finance that has culminated in the founding of his firm. Dondero founded the firm in 1993 and built it into one of the most successful in the finance industry. The firm specializes in collateralized loan obligations and is therefore among the leading investment firms when it comes to managing a number of credit securities. As well as providing credit management, Dondero’s firm also provides hedge funds and private equity securities in order to help manage the capital of many of the firm’s clients. With the firm’s success, Dondero has expanded the firm to other parts of the world. Now, the firm has locations in New York City, Singapore, South Korea and Brazil.


Dondero attended the University of Virginia where he graduated with top honors. He majored in both accounting and finance which provided him with the education foundation for his occupation. When he first began his working career, he held a position at an investment firm as a credit analyst. Over time, he would hold other more significant positions in the industry. His last position during his working career was that of a chief investment officer. When he held this position, he would oversee and manage large sums of capital for major corporations. When not working, James devotes time to philanthropic activities.

Jason Hope is one of the most prominent serial entrepreneurs based in the United States. According to his journal, he explains that the internet is the only platform capable of relaying the message to everyone in the world in a fraction of a second. Because the technology used to develop the Internet, it has become one of the most resourceful commodities to the human life in the modern lifestyle.

Jason Hope has made his mission to write and develop technology regarding the Internet as a way of living. Jason Hope also has strong faith in the Internet of Things. In the recent past, he has his focus on the commendation of aspects regarding the Internet and other factors.

Jason Hope has achieved his mission through scalability and modernization as a way of developing working capital. According to him, various things have been made manifest through the inset of the internet. While it was conceived as the only way to connect computers and share resources, it is now made to connect lives and particular aspects of human beings. The internet is also a connection of devices and commodities. In the recent past, various people have secured job opportunities through the web as a way of life in a modern world.

In the recent past, we have seen an influx of businesses and companies taking their services and products on the Internet. This is a way of conforming to the latest technology and the ways of development in a manner which is unparalleled in the industry. Jason Hope has written numerous articles concerning the importance and downside parts of the Internet. While he works to inform the people on the benefits of the web, he has his focus on entrepreneurship. Jason Hope is now regarded as one of the most prominent Internet serial entrepreneur based in the United States.

More articles about Jason Hope’s Life and Career at

Anesthesiology plays a vital role in medical care and without it, patients would have an extremely hard time getting through medical procedures. Capital Anesthesiology Association is one of the leading independent practices of anesthesiology specialization in the country. There are well over 130 certified registered nurse anesthetists and up to 80 physicians under this umbrella. The organization has been around since the early 70’s and it has grown into the powerhouse of today. Capital Anesthesiology Association provides top notch care for up to 2 medical facilities in the Austin, Texas Metro Area.


Whether it’s a Level 1 Trauma Center, High Acuity Hospitals, or Ambulatory Surgical Centers, CAA has you covered. Here are some of the local medical facilities that are being served throughout the area:


  • Dell Children’s Medical Center
  • Seton Hayes
  • Seton Medical Center
  • Strictly Pediatrics
  • Texas Surgical Center
  • And many more


This only scratches the surface of area medical facilities that are being served. In addition to high quality clinical services, Capital Anesthesiology Association provides high quality administrative services as well. Dealing with insurance carriers can be frustrating, but CAA helps all patients/customers with the billing process by assisting with top notch support. All in all, when it comes down to getting this done efficiently and effectively, Capital Anesthesiology Association sits at the top of the apex.

Refer also to this related link


Most New Years resolutions are forgotten by the second week of January, but when it comes to your business you need to see them through. One resolution you should seriously consider keeping is improving your reputation online.

Online reputation management is becoming more important, as consumers increasingly look for reviews and recommendations online before making a purchase. With these five tips, your reputation will glow in the coming year.

  1. Search For Your Name

One of the easiest ways to see what is being said about your and your company is to Google yourself. Notice the good and bad things that are being said. While you cannot delete the negative things that are being said, you can create more positive content to push the bad stuff off page one. But you have to start somewhere.

  1. Take An Inventory Of Your Social Profiles

Go back and look at all the posts you have made to your social networks. Delete anything that does not fit with the image you are now trying to portray. Political or religious posts may turn off potential customers. If you have to ask if a particular post is appropriate, it probably isn’t.

  1. Email Voice

Go through and look at the sent items in your email server. Do you come off as professional? How do you communicate with co-workers and customers? Make your voice consistent in all your correspondence.

  1. Rewrite Your Bio

Write a short bio that accurately describes who you are and what you do. Once you have it honed and ready, post it across all your social profiles and the About Me section on your website. The more this version is read, the more it becomes part of your reputation.

  1. Get Your Name Out There

The best way to create a positive reputation is to publish content consistently. Write for your own website and then branch out into guest blogging for sites in your industry. You should also be publishing on LinkedIn and Medium regularly.

A new year is an opportunity to improve your online reputation, but you do not have to wait to implement an online reputation management strategy. Start today and make consistent efforts throughout the year.

Dick DeVos is known for his many different ventures in business. It is, however, his work at Amway that put him and his career in the limelight.


He began his business ventures when he was young, but his career began in 1974 when he joined Amway Corporation. Before joining the company, Dick was a student at the Northwood University where he did his Bachelor in Business Administration. He did also attend the Harvard Business School although he didn’t graduate.


At Amway, he worked in different departments including; marketing, sale, finance, research, manufacturing, research and development. Through his different projects, he was promoted to the position of a vice president. He was charged with the responsibility of running the different company operations in all the eighteen countries. Later in 1993 he became the president of the company and served in the same position until 2002.


His family acquired the Orlando Magic in 1991 which is a basketball team. He later became the president of the company. He, however, held this position for three years. In 2005, the president of the company, Richard DeVos, his father, split the company among his different company and Dick became a part owner of the company.


After he had left the Amway Corporation, he became the president of the Windquest Group. This is a privately owned company that deals with technology and manufacturing.


In 1993, he and his wife became the co-chairs of the Education Freedom Fund which supports children from low-income families.




He has been involved in different charity works. He is the president of the Dick and Betsy Family Foundation which he has been involved in different projects.


In 2010, he opened an aviation academy in West Michigan which was the first aviation public school in the Nation.


Together with his wife Betsy DeVos he has been involved in arts funding. His foundation has been involved in supporting the Art Prize since 2009. They also committed millions to the Kennedy Center of Arts Management approximately $22.5 million. This institute offers training to art managers.


Scholarships are also another venture that he has been involved in. The Dick and Betsy Scholarship was established in 2008. This is a scholarship that supports the students in MA, MS, and MBA studying at the Thunderbird School of Global Management. The scholarships are offered to students from developing countries.




Dick DeVos was awarded the Spectrum Health Foundation Art of Giving Award in 2010 for his philanthropy work.

An article published in Ideamensch during the month of December, 2016, summarizes an interview with Adam Milstein, the managing partner of Hager Pacific Properties. He talks about his past, his current work, his philosophy about real estate, and what motivates and drives him to succeed.


Milstein came to the United States from Israel in 1981 for the purpose of attending the University of Southern California to pursue a MBA degree. Upon graduation he stayed in Southern California and starting a career in commercial real estate as a broker. He used his life experience in Israel which included service in the armed forces. This put him ahead of the typical graduate. After three years as a broker, he moved into the area of real estate investment. This led to the formation of Hager Pacific Properties along with his partner David Hager.


Adam Milstein is a hard worker who enjoys his work. He is persistent and consistent in his approach to his business. He says you must follow up every contact. Realize that there are no short cuts in real estate investing and that you must be in it for the long haul. Success does not come quickly but is the result of hard work and the passage of time.


When asked for the one idea he follows over and over, it is to understand the issue at hand. Do not rely on anyone else. Understand the problem and be part of the solution.


Milstein is involved in several charitable causes including an organization that provides free books in Hebrew for Jewish families. Family is the most part of his life. He says the best money he ever spends is for dinner with wife and children. Adam Milstein gives back to the community from his success in real estate.


Adam Milstein does not set specific goals. He just loves his work and believes that consistent hard work pays off in the long run. Once you realize commercial real estate investing is not a get rich scheme, you can work hard and success will come. Real estate investing takes patience and the passage of time.

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